plsC [2018-10-17 13:55:45]

acyl-ACP:1-acylglycerolphosphate acyltransferase

locus: BSU09540

pI: 9.98

mw: 21.78 kDa

protein length: 199 aa

gene length: 597 bp

function: biosynthesis of phospholipids

product: acyl-ACP:1-acylglycerolphosphate acyltransferase

essential: yes

ec: 2.3.1.51

synonyms: yhdO

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,031,395 → 1,031,994

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Structure

• [PDB|5KYM] (from Thermotoga maritima) [pubmed|28714993]

[SW|Localization]

• cell membrane at the septum [Pubmed|15743965]

Expression and Regulation

Operons

• genes: [gene|4DF9B105ABA64AFD5106EE75FCC9EFAB52BEFC83|yhdN]-[gene|FC05D5FC95CEDC4B4A04040C86170D185528B9FF|plsC]
  description: [Pubmed|10220166]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|10220166,15805528], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

  regulatory mechanism

  • [protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]: repression, [Pubmed|12737802], in [regulon|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR regulon]

  regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|10220166,15805528]

Biological materials

Mutant

• MGNA-B483 (yhdO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1482 NBRP B. subtilis, Japan]

References

• 12737802,17557823,24574048,15743965,28714993